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Folinic acid
CAS No. 58-05-9
Folinic acid( —— )
Catalog No. M33999 CAS No. 58-05-9
Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 31 | In Stock |
|
| 25MG | 46 | In Stock |
|
| 50MG | 64 | In Stock |
|
| 100MG | 90 | In Stock |
|
| 500MG | 215 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFolinic acid
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NoteResearch use only, not for human use.
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Brief DescriptionFolinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.
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DescriptionFolinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity.
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In Vitro——
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In VivoAnimal Model:24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)Dosage:7.0 mg/kg Administration:Intraperitoneal injection; every second day; for 3 weeks Result:Following MTX administration appears to reverse this growth inhibition.
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetEndogenous Metabolite
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RecptorEndogenous Metabolite | Antifolate
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Research Area——
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Indication——
Chemical Information
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CAS Number58-05-9
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Formula Weight473.44
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Molecular FormulaC20H23N7O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (528.05 mM; Ultrasonic )
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SMILESNc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)N(C=O)c2c(=O)[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.?
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